Targeting the androgen receptor in metastatic castrate-resistant prostate cancer: A review

被引：30

作者：

Anantharaman, Archana ^{[1
]}

Friedlander, Terence W. ^{[1
]}

机构：

[1] UCSF Helen Diller Family Comprehens Canc Ctr, Genitourinary Med Oncol Program, San Francisco, CA USA

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2016年 / 34卷 / 08期

关键词：

Castration-resistant prostate cancer; Androgen receptor; CAG REPEAT LENGTH; ACETATE PLUS PREDNISONE; ABIRATERONE ACETATE; DOUBLE-BLIND; INDEPENDENT GROWTH; INCREASED SURVIVAL; PATIENTS PTS; L INHIBITOR; PHASE-II; GENE;

D O I：

10.1016/j.urolonc.2015.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite recent advances in the treatment of advanced prostate cancer (PCa), metastatic castrate-resistant PCa remains incurable at this time. The androgen receptor (AR) plays a key role in the development and progression of PCa, continuing to be active in most patients even after the development of castration resistance. Here, we aim to more closely review the mechanisms by which AR signaling is maintained, including AR overexpression/overamplification, intracrine androgen synthesis, AR mutations, and the development of AR splice variants. We also review therapies targeting each of these mechanisms. We also discuss the potential role of AR-CAG repeats and AR splice variants as potential biomarkers of response to hormonal manipulation therapies. Published by Elsevier Inc.

引用

页码：356 / 367

页数：12

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