Successful adjuvant treatment of severe bullous pemphigoid by tryptophan immunoadsorption

被引：18

作者：

Herrero-González, JE

Sitaru, C

Klinker, E

Bröcker, EB

Zillikens, D

机构：

[1] Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany

[2] Univ Wurzburg, Dept Transfus Med & Immunochematol, Wurzburg, Germany

[3] Univ Wurzburg, Dept Dermatol, Wurzburg, Germany

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2005年 / 30卷 / 05期

关键词：

D O I：

10.1111/j.1365-2230.2005.01853.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with circulating autoantibodies to the hemidesmosomal antigens BP180 and BP230. We report two cases of therapy-refractory BP adjuvantly treated by tryptophan immunoadsorption. In both patients, this treatment was associated with rapid clinical improvement and reduction in the required corticosteroid dosage. In addition, levels of circulating anti-BP180 autoantibodies decreased markedly. Antibodies that were eluted from the tryptophan matrix bound to BP180 and induced dermal-epidermal separation in cryosections of human skin. Our observations suggest that immunoadsorption may be a helpful adjuvant treatment in severe BP.

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收藏

页码：519 / 522

页数：4

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