Two-dimensional infrared spectroscopy of photoswitchable peptides

被引：142

作者：

Hamm, Peter ^{[1
]}

Helbing, Jan ^{[1
]}

Bredenbeck, Jens ^{[1
]}

机构：

[1] Univ Zurich, Inst Phys Chem, CH-8057 Zurich, Switzerland

来源：

ANNUAL REVIEW OF PHYSICAL CHEMISTRY | 2008年 / 59卷

关键词：

2D-IR spectroscopy; ultrafast time-resolved spectroscopy; multidimensional spectroscopy; peptide dynamics; peptide folding;

D O I：

10.1146/annurev.physchem.59.032607.093757

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We present a detailed discussion of the complimentary fields of the application of two-dimensional infrared (2D-IR) spectroscopy in comparison with two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy. Transient 2D-IR (T2D-IR) spectroscopy of nonequilibrium ensembles is probably one of the most promising strengths of 2D-IR spectroscopy, as the possibilities of 2D-NMR spectroscopy are limited in this regime. T2D-IR spectroscopy uniquely combines ultrafast time resolution with microscopic structural resolution. In this article we summarize our recent efforts to investigate the ultrafast structural dynamics of small peptides, such as the unfolding of peptide secondary structure motifs. The work requires two ingredients: 2D-IR spectroscopy and the possibility of triggering a structural transition of a peptide on an ultrafast timescale using embedded or intrinsic photoswitches. Several photoswitches have been tested, and we discuss our progress in merging these two pathways of research.

引用

页码：291 / 317

页数：27

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