A neuroanatomic model for depression

被引：49

作者：

Byrum, CE ^{[1
]}

Ahearn, EP ^{[1
]}

Krishnan, KRR ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1999年 / 23卷 / 02期

关键词：

affective; amygdala; basal ganglia; depression; limbic system; monoamines; mood; neuroanatomy; neuroimaging;

D O I：

10.1016/S0278-5846(98)00106-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Emotion and mood, once thought to be governed solely by the limbic system of the brain, now are thought to be influenced by numerous nonlimbic central nervous system structures as well. 2. The present review discusses several important brain structures and neuroanatomic pathways thought to be involved in affect and mood disorders, including the amygdala, frontal neocortex, cingulate gyrus, basal ganglia, and the monoamine systems. 3. The authors propose a specific neuroanatomic model for depression that emphasizes that a distributed system of extensively interconnected CNS structures mediates emotion and affect.

引用

页码：175 / 193

页数：19

共 85 条

[1]

ADOLPHS R, 1995, J NEUROSCI, V15, P5879

[2]

AGGLETON JP, 1992, AMYGDALA, P483

[3] FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING [J].

ALEXANDER, GE ;

CRUTCHER, MD .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :266-271

[4] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[5] AN ANATOMICALLY CONSTRAINED NEURAL-NETWORK MODEL OF FEAR CONDITIONING [J].

ARMONY, JL ;

COHEN, JD ;

SERVANSCHREIBER, D ;

LEDOUX, JE .

BEHAVIORAL NEUROSCIENCE, 1995, 109 (02) :246-257

[6] SINGLE PHOTON-EMISSION TOMOGRAPHY WITH TC-99M-EXAMETAZIME IN MAJOR DEPRESSION AND THE PATTERN OF BRAIN ACTIVITY UNDERLYING THE PSYCHOTIC NEUROTIC CONTINUUM [J].

AUSTIN, MP ;

DOUGALL, N ;

ROSS, M ;

MURRAY, C ;

OCARROLL, RE ;

MOFFOOT, A ;

EBMEIER, KP ;

GOODWIN, GM .

JOURNAL OF AFFECTIVE DISORDERS, 1992, 26 (01) :31-43

[7]

BAGSDALE CW, 1990, P NATL ACAD SCI USA, V87, P6196

[8] AFFERENT CONNECTIONS TO THE LATERAL HYPOTHALAMUS - A HORSERADISH-PEROXIDASE STUDY IN THE RAT [J].

BARONE, FC ;

WAYNER, MJ ;

SCHAROUN, SL ;

GUEVARAAGUILAR, R ;

AGUILARBATURONI, HU .

BRAIN RESEARCH BULLETIN, 1981, 7 (01) :75-88

[9]

BAXTER LR, 1985, ARCH GEN PSYCHIAT, V42, P441

[10] THE ANATOMY OF MELANCHOLIA - FOCAL ABNORMALITIES OF CEREBRAL BLOOD-FLOW IN MAJOR DEPRESSION [J].

BENCH, CJ ;

FRISTON, KJ ;

BROWN, RG ;

SCOTT, LC ;

FRACKOWIAK, RSJ ;

DOLAN, RJ .

PSYCHOLOGICAL MEDICINE, 1992, 22 (03) :607-615

← 1 2 3 4 5 6 7 8 9 →