Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial

被引：16

作者：

Bobe, Gerd ^{[1
,2
,3
]}

Murphy, Gwen ^{[4
]}

Albert, Paul S. ^{[5
]}

Sansbury, Leah B. ^{[6
]}

Lanza, Elaine ^{[3
]}

Schatzkin, Arthur ^{[4
]}

Cross, Amanda J. ^{[4
]}

机构：

[1] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA

[2] Oregon State Univ, Dept Anim Sci, Corvallis, OR 97331 USA

[3] NCI, Lab Canc Prevent, Ctr Canc Res, NIH,DHHS, Frederick, MD 21701 USA

[4] NCI, Nutr Epidemiol Branch, DCEG, NIH, Rockville, MD USA

[5] NICHHD, Biostat & Bioinformat Branch, NIH, Rockville, MD USA

[6] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH, Rockville, MD USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2012年 / 130卷 / 07期

关键词：

cancer prevention; colorectal adenoma; colorectal cancer; lignans; proanthocyanidins; PHYTOESTROGEN INTAKE; CANCER RISK; INCLUDING ISOFLAVONES; POSTMENOPAUSAL WOMEN; FLAVONOID INTAKE; FOOD SOURCES; HIGH-FIBER; LOW-FAT; ENTEROLACTONE; COLON;

D O I：

10.1002/ijc.26184

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex-specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.223.52, p trend = 0.004) but not in men (p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women.

引用

页码：1649 / 1659

页数：11

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