Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

被引：81

作者：

Kim, CH

Takamiya, K

Petralia, RS

Sattler, R

Yu, S

Zhou, WG

Kalb, R

Wenthold, R

Huganir, R ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[3] Natl Inst Deafness & Other Commun Disorders, Neurochem Lab, NIH, Bethesda, MD 20892 USA

[4] Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 08期

关键词：

D O I：

10.1038/nn1432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

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页码：985 / 987

页数：3

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