Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation

被引：140

作者：

Ikeda, T

Kawaguchi, H

Kamekura, S

Ogata, N

Mori, Y

Nakamura, K

Ikegawa, S

Chung, UI

机构：

[1] Tokyo Univ Hosp, Div Tissue Engn, Bunkyo Ku, Tokyo 1138655, Japan

[2] Tokyo Univ Hosp, Div Motor & Sensory Syst Med, Tokyo 113, Japan

[3] RIKEN, SNP Res Ctr, Tokyo, Japan

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2005年 / 23卷 / 05期

关键词：

cartilage; formation; regeneration; Sox;

D O I：

10.1007/s00774-005-0610-y

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

引用

收藏

页码：337 / 340

页数：4

相关论文

共 29 条

[1]

The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 [J].

Akiyama, H ;

Chaboissier, MC ;

Martin, JF ;

Schedl, A ;

de Crombrugghe, B .

GENES & DEVELOPMENT, 2002, 16 (21) :2813-2828

[2]

Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites [J].

Ambrosetti, DC ;

Basilico, C ;

Dailey, L .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) :6321-6329

[3]

SOX9 directly regulates the type-II collagen gene [J].

Bell, DM ;

Leung, KKH ;

Wheatley, SC ;

Ng, LJ ;

Zhou, S ;

Ling, KW ;

Sham, MH ;

Koopman, P ;

Tam, PPL ;

Cheah, KSE .

NATURE GENETICS, 1997, 16 (02) :174-178

[4]

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization [J].

Bi, WM ;

Huang, WD ;

Whitworth, DJ ;

Deng, JM ;

Zhang, ZP ;

Behringer, RR ;

de Crombrugghe, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6698-6703

[5]

Sox9 is required for cartilage formation [J].

Bi, WM ;

Deng, JM ;

Zhang, ZP ;

Behringer, RR ;

de Crombrugghe, B .

NATURE GENETICS, 1999, 22 (01) :85-89

[6]

Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer [J].

Bridgewater, LC ;

Lefebvre, V ;

de Crombrugghe, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (24) :14998-15006

[7]

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development [J].

Chung, UI ;

Schipani, E ;

McMahon, AP ;

Kronenberg, HM .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :295-304

[8]

Regulatory mechanisms in the pathways of cartilage and bone formation [J].

de Crombrugghe, B ;

Lefebvre, W .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (06) :721-727

[9]

AN SRY-RELATED GENE EXPRESSED DURING SPERMATOGENESIS IN THE MOUSE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN [J].

DENNY, P ;

SWIFT, S ;

CONNOR, F ;

ASHWORTH, A .

EMBO JOURNAL, 1992, 11 (10) :3705-3712

[10]

CAMPOMELIC DYSPLASIA AND AUTOSOMAL SEX REVERSAL CAUSED BY MUTATIONS IN AN SRY-RELATED GENE [J].

FOSTER, JW ;

DOMINGUEZSTEGLICH, MA ;

GUIOLI, S ;

KWOK, C ;

WELLER, PA ;

STEVANOVIC, M ;

WEISSENBACH, J ;

MANSOUR, S ;

YOUNG, ID ;

GOODFELLOW, PN ;

BROOK, JD ;

SCHAFER, AJ .

NATURE, 1994, 372 (6506) :525-530