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Detection, clinical relevance and specific biological properties of disseminating tumour cells

被引：988
作者：
Pantel, Klaus [1 ]
Brakenhoff, Ruud H. [2 ]
Brandt, Burkhard [1 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Inst Tumour Biol, Ctr Med Expt, Hamburg, Germany
[2] Vrije Univ Amsterdam, Med Ctr, Sect Tumour Biol, Dept Otolaryngol Head & Neck Surg, NL-1081 HV Amsterdam, Netherlands
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 05期
关键词：
D O I：
10.1038/nrc2375
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 [肿瘤学];
摘要：
Most cancer deaths are caused by haematogenous metastatic spread and subsequent growth of tumour cells at distant organs. Disseminating tumour cells present in the peripheral blood and bone marrow can now be detected and characterized at the single-cell level. These cells are highly relevant to the study of the biology of early metastatic spread and provide a diagnostic source in patients with overt metastases. Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment.
引用
收藏
页码：329 / 340
页数：12
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