Enantioconvergent transformation of racemic cis-dialkyl substituted epoxides to (R,R) threo diols by microsomal epoxide hydrolase catalysed hydrolysis

被引：17

作者：

Bellucci, G

Chiappe, C

Cordoni, A

Ingrosso, G

机构：

[1] DIPARTIMENTO CHIM BIOORGAN,I-36126 PISA,ITALY

[2] DIPARTIMENTO BIOL,I-73100 LECCE,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(96)02094-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of (+/-)-9,10-epoxystearic acid (1b), cis-(+/-)-5,6-epoxyhexadecane (1c) and cis-(+/-)-11,12-epoxyhexadecan-1-ol (1d) as well as the meso cis-9,10-epoxyoctadecane (1a) undergo microsomal epoxide hydrolase catalyzed hydration at the (S) carbon to give the corresponding (R,R) threo diols in a >90 e.e. Copyright (C) 1996 Elsevier Science Ltd

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页码：9089 / 9092

页数：4

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