Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions

被引：149

作者：

So, Jae-Seon ^{[1
]}

Kwon, Ho-Keun ^{[1
]}

Lee, Choong-Gu ^{[1
]}

Yi, Hwa-Jung ^{[1
]}

Park, Jin-A. ^{[1
]}

Lim, So-Yeon ^{[2
]}

Hwang, Ki-Chul ^{[2
]}

Jeon, Young Ho ^{[3
]}

Im, Sin-Hyeog ^{[1
]}

机构：

[1] GIST, Dept Life Sci, Kwangju 500712, South Korea

[2] Yonsei Univ, Coll Med, Cardiovasc Res Inst, Div Cardiol, Seoul 120752, South Korea

[3] KBSI, Bio Magnet Resonance Res Ctr, Chungbuk 363883, South Korea

来源：

MOLECULAR IMMUNOLOGY | 2008年 / 45卷 / 09期

关键词：

rheumatoid arthritis; collagen-induced arthritis; Lactobacillus casei; probiotics; CD4(+) T cells; cytokines;

D O I：

10.1016/j.molimm.2007.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating the effector functions of CD4(+) T cells. Oral administration of L. casei suppressed coil agen-induced arthritis (CIA) and reduced paw swelling, lymphocyte infiltration and destruction of cartilage tissue. L. casei administration reduced type II collagen (CII)-reactive proinflammatory molecules (IL-1 beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha and Cox-2) by CD4(+) T cells. L. casei administration also reduced translocation of NF-kappa B into nucleus and CII-reactive Th1-type IgG isotypes IgG2a and IgG2b, while up-regulating immunoregulatory IL-10 levels. Our results suggest that oral administration of L casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2690 / 2699

页数：10

共 61 条

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