B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications

被引:32
作者
Tuscano, JM [1 ]
Harris, GS
Tedder, TE
机构
[1] Univ Calif Davis, Med Ctr, Dept Internal Med, Sacramento, CA 95817 USA
[2] Vet Adm No Calif Hlth Care Syst, Martinez, CA USA
[3] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA
关键词
B lymphocyte; CD19; CD20; CD22; signal transduction; immunotherapy;
D O I
10.1016/S1568-9972(02)00148-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Abnormal B lymphocytes influence the pathogenesis of many autoimmune diseases, in addition to serving as the origin of pathogenic autoantibodies. Although aberrant B cell function and autoimmunity have complex polygenic origins, recent studies in mouse models of autoimmune diseases have revealed overlapping defects in signal transduction pathways that alter B cell survival or activation, and lead to an autoimmune phenotype. Discovery of these important signaling pathways in mice has lead to an intense search for B cell abnormalities that correlate with autoimmune diseases in humans. This search has identified potential targets for therapeutic intervention that are the focus of planned and ongoing human clinical trials. This promises an arsenal of highly targeted, less toxic therapies focused on restoring normal B cell function that will eliminate pathogenic autoantibodies and replace the current use of immunosuppressive drugs. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:101 / 108
页数:8
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