Role of transposable elements in trypanosomatids

被引:27
作者
Bringaud, Frederic [1 ]
Ghedin, Elodie [2 ]
El-Sayed, Najib M. A. [3 ,4 ]
Papadopoulou, Barbara [5 ,6 ]
机构
[1] Univ Bordeaux 2, CNRS, Lab Resonance Magnet Syst Biol, UMR 5536, F-33076 Bordeaux, France
[2] Univ Pittsburgh, Sch Med, Dept Med, Div Infect Dis, Pittsburgh, PA 15261 USA
[3] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
[4] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA
[5] Univ Laval, Univ Laval Res Ctr, Ctr Hosp, Res Ctr Infect Dis, Quebec City, PQ G1V 4G2, Canada
[6] Univ Laval, Fac Med, Dept Med Biol, Quebec City, PQ G1V 4G2, Canada
关键词
transposable element; retroposon; Trypanosoma; Leishmania; cellular function; evolution; domestication; regulation of mRNA stability; gene expression;
D O I
10.1016/j.micinf.2008.02.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
Transposable elements constitute 2-5% of the genome content in trypanosomatid parasites. Some of them are involved in critical cellular functions, such as the regulation of gene expression in Leishmania spp. In this review, we highlight the remarkable role extinct transposable elements can play as the source of potential new functions. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:575 / 581
页数:7
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