Noradrenergic modulation of tactile responses in rat cortex. Current source-density and unit analyses

被引:13
作者
Lecas, JC [1 ]
机构
[1] Univ Paris 06, Inst Neurosci, Dept Neuromodulat & Proc Cognit, CNRS,UMR C7624, F-75005 Paris, France
来源
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 2001年 / 324卷 / 01期
关键词
rat; sensorimotor cortex; locus coeruleus stimulation; noradrenaline; CSD; unit activity;
D O I
10.1016/S0764-4469(00)01276-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study describes the noradrenergic modulation of tactile afferent information in the sensorimotor cortex of urethane-anesthetized rats. Synaptic and spike responses to a mechanical stimulation of the hand palm were evaluated by means of current source-density analysis and unit activity recording in all cortical layers. Results showed that activation of the locus coeruleus decreased and shortened efferent synaptic excitation in supragranular, but not in deep layers. On the average, unit responses exhibited facilitated latency, moderately increased amplitude, enhanced postexcitatory inhibition and synchronization of responses across layers. The apparent paradox of this global phasic facilitation correlated with a decrease in input synaptic currents was discussed according to hypotheses which might explain its functional significance. (C) 2001 Academie des sciences / Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:33 / 44
页数:12
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