Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV)

被引：39

作者：

Bae, Green ^{[1
]}

Yu, Jae-Rang ^{[1
]}

Lee, Jun ^{[1
]}

Chang, Jun ^{[1
]}

Seo, Eun-Kyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Ctr Cell Signaling & Drug Discovery Res, Seoul 120750, South Korea

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 09期

关键词：

D O I：

10.1002/cbdv.200790181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three known phenolic compounds, (-)-(R)-nyasol (=4,4'-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3) - isolated from the rhizomes of Anemarrhena asphodeloides - were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 =1.15 mu m). In addition, the known, but inactive, compound 'trans-N-(para-coumaroyl)tyramine' (=(2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide;4) was isolated from this plant for the first time.

引用

页码：2231 / 2235

页数：5

共 30 条

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