Photodynamic antimicrobial chemotherapy (PACT)

被引:1000
作者
Wainwright, M [1 ]
机构
[1] Univ Cent Lancashire, Dept Chem, Photochemotherapy Grp, Preston PR1 2HE, Lancs, England
关键词
D O I
10.1093/jac/42.1.13
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Whereas the photodynamic therapy (PDT) of cancer has recently shown rapid clinical acceptance, photodynamic antimicrobial chemotherapy (PACT)-which predates the related cancer regimen-is not widely appreciated. Like PDT, PACT utilizes photosensitizers and visible or ultraviolet light in order to give a phototoxic response, normally via oxidative damage. Currently, the major use of PACT is in the disinfection of blood products, particularly for viral inactivation, although more clinically-based protocols are being developed, e.g. in the treatment of oral infection. The technique has been shown to be effective in vitro against bacteria (including drug-resistant strains), yeasts, viruses and parasites. A wide range of photosensitizers, both natural and synthetic, is available with differing physicochemical make-up and light-absorption properties. PACT is proposed as a potential, low-cost approach to the treatment of locally occurring infection.
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页码:13 / 28
页数:16
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