Effect of genetic modifiers on cerebral lesions in Fabry disease

被引：66

作者：

Altarescu, G

Moore, DF

Schiffmann, R

机构：

[1] NINDS, Dev & Metab Neurol Branch, NIH, Bethesda, MD 20892 USA

[2] Shaare Zedek Med Ctr, Dept Internal Med, Jerusalem, Israel

[3] Univ Manitoba, Dept Internal Med, Neurol Sect, Winnipeg, MB R3T 2N2, Canada

来源：

NEUROLOGY | 2005年 / 64卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000166000.24321.4F

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fabry disease is associated with increased risk of premature stroke and presumptive ischemic cerebral lesions. In 57 consecutive patients, 35% of whom had lesions on brain MRI, the authors found that genotypes of polymorphisms G-174C of interleukin-6, G894T of endothelial nitric oxide synthase, factor V G1691A mutation, and the A-13G and G79A of protein Z were all significantly associated with cerebral lesions. These findings suggest that these proteins modulate Fabry cerebral vasculopathy.

引用

页码：2148 / 2150

页数：3

共 10 条

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