Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers

被引：32

作者：

Fernandes, Amanda Velinna ^{[1
]}

Pydi, Chinna Raja ^{[1
]}

Verma, Ruchi ^{[2
]}

Jose, Jobin ^{[3
]}

Kumar, Lalit ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Udupi, Karnataka, India

[2] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Chem, Udupi, Karnataka, India

[3] NITTE Deemed Univ, NGSM Inst Pharmaceut Sci, Dept Pharmaceut, Mangalore, India

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2020年 / 56卷

关键词：

Fluconazole; NLCs; Nanostructured lipid carriers; Fungal infections; Full factorial design; Design of experiment; DRUG-DELIVERY; ANTIFUNGAL AGENTS; NANOPARTICLES SLN; DERMAL DELIVERY; FORMULATION; SURFACTANT; PHARMACOKINETICS; DEGRADATION; SELECTION; FILMS;

D O I：

10.1590/s2175-97902019000318069

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 +/- 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 +/- 7.45% and 87 +/- 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 +/- 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.

引用

页数：14

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