Safety of Nonsteroidal Antiinflammatory Drugs in Patients with Cardiovascular Disease

被引：30

作者：

Danelich, Ilya M. ^{[1
]}

Wright, Sampaguita S. ^{[1
]}

Lose, Jennifer M. ^{[1
]}

Tefft, Brittany J. ^{[1
]}

Cicci, Jonathan D. ^{[2
]}

Reed, Brent N. ^{[3
]}

机构：

[1] Mayo Clin, Dept Pharm, Rochester, MN USA

[2] Univ North Carolina Hosp, Dept Pharm, Chapel Hill, NC USA

[3] Univ Maryland, Sch Pharm, Dept Pharm Practice & Sci, Baltimore, MD 21201 USA

来源：

PHARMACOTHERAPY | 2015年 / 35卷 / 05期

关键词：

nonsteroidal antiinflammatory drugs; cardiovascular disease; cardiac surgery; noncardiac surgery; bleeding; CONGESTIVE-HEART-FAILURE; MYOCARDIAL-INFARCTION; ELDERLY-PATIENTS; BLOOD-PRESSURE; CYCLOOXYGENASE-2; INHIBITORS; COX-2; INCREASED RISK; NSAIDS; OSTEOARTHRITIS; CELECOXIB;

D O I：

10.1002/phar.1584

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Nonsteroidal antiinflammatory drugs (NSAIDs) are used in the management of a variety of conditions, but their prevalence is likely underreported as a result of widespread availability and the perception that nonprescription therapies are unnecessary to report during medication history taking. However, NSAIDs are associated with a number of adverse effects, especially in patients with cardiovascular disease (CVD). Patients with CVD and comorbidities for which NSAIDs may provide symptomatic relief (e.g., osteoarthritis, rheumatoid arthritis) tend to be older, which places them at greater risk of harm. For these reasons, the use of NSAIDs in patients with CVD is a significant public health concern. An understanding of the risks associated with NSAIDs is critical for clinicians across practice settings. In this review, we detail the safety of NSAIDs in patients with CVD, provide recommendations on their use in specific disease states, and discuss therapeutic alternatives.

引用

页码：520 / 535

页数：16

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