Alteration of rCBF in Alzheimer's disease patients with delusions of theft

被引：37

作者：

Fukuhara, R

Ikeda, M

Nebu, A

Kikuchi, T

Maki, N

Hokoishi, K

Shigenobu, K

Komori, K

Tanabe, H

机构：

[1] Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan

[2] Ehime Univ, Sch Med, Dept Radiol, Shigenobu, Ehime 7910295, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 11期

关键词：

age; sex; cognitive impairment-matched case-controlled study; Alzheimer's disease; Alzheimer's disease Assessment Scale cognitive; subscale (ADAScog.); delusions of theft; Neuropsychiatric Inventory (NPI); Statistical Parametric Mapping (SPM); Tc-99m-HMPAO SPECT;

D O I：

10.1097/00001756-200108080-00037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the neural substrate of the delusion of theft in patients with Alzheimer's disease (AD). Nine AD patients with only one type of delusion (delusions of theft) and nine age, cognitive function-matched AD patients without any type of delusions were selected from 334 consecutive outpatients of Ehime University Hospital. All subjects underwent Tc-99m-HMPAO SPECT scanning, and SPECT images were analyzed by Statistical Parametric Mapping (SPM). AD patients with delusions of theft showed significant hypoperfusion in the right medial posterior parietal region compared to patients without delusions. Our data suggest that attention impairment or lack of awareness of illness caused by right parietal dysfunction might play a role in producing the delusion of theft. NeuroReport 12:2473-2476 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：2473 / 2476

页数：4

共 23 条

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