Properties and reactions of substituted 1,2-thiazetidine 1,1-dioxides:: Chiral mono- and bicyclic 1,2-thiazetidine 1,1-dioxides from α-amino acids

被引：49

作者：

Meinzer, A ^{[1
]}

Breckel, A ^{[1
]}

Abu Thaher, B ^{[1
]}

Manicone, N ^{[1
]}

Otto, HH ^{[1
]}

机构：

[1] Univ Greifswald, Inst Pharm, Dept Pharmaceut Med Chem, D-17487 Greifswald, Germany

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 01期

关键词：

D O I：

10.1002/hlca.200490021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New chiral mono- and bicyclic beta-sultams, valuable building blocks for drug synthesis, have been prepared from L-Ala, L-Val, L-Leu, L-Ile, L-Phe, L-Cys, L-Ser, L-Thr, and D-penicillamine by transformation of the COOH group into a methylsulfonyl chloride function, followed by cyclization under basic conditions. Selected properties, derivatives, and reactions of the beta-sultams are described.

引用

页码：90 / 105

页数：16

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