Dynamics of anisotropic tissue growth

被引：68

作者：

Bittig, Thomas ^{[3
]}

Wartlick, Ortrud ^{[1
,2
]}

Kicheva, Anna ^{[1
,2
]}

Gonzalez-Gaitan, Marcos ^{[1
,2
]}

Juelicher, Frank ^{[3
]}

机构：

[1] Univ Geneva, Dept Biochem, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Dept Mol Biol, CH-1211 Geneva 4, Switzerland

[3] Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany

来源：

NEW JOURNAL OF PHYSICS | 2008年 / 10卷

关键词：

D O I：

10.1088/1367-2630/10/6/063001

中图分类号：

O4 [物理学];

学科分类号：

0702 [物理学];

摘要：

We study the mechanics of tissue growth via cell division and cell death (apoptosis). The rearrangements of cells can on large scales and times be captured by a continuum theory which describes the tissue as an effective viscous material with active stresses generated by cell division. We study the effects of anisotropies of cell division on cell rearrangements and show that average cellular trajectories exhibit anisotropic scaling behaviors. If cell division and apoptosis balance, there is no net growth, but for anisotropic cell division the tissue undergoes spontaneous shear deformations. Our description is relevant for the study of developing tissues such as the imaginal disks of the fruit fly Drosophila melanogaster, which grow anisotropically.

引用

页数：11

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