Relationship between haemolysis production and resistance to fluoroquinolones among clinical isolates of Escherichia coli

被引：50

作者：

Martínez-Martínez, L

Fernández, F

Perea, EJ

机构：

[1] Sch Med, Dept Microbiol, Seville 41080, Spain

[2] Univ Hosp Virgen Macarena, Dept Microbiol, Seville, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1093/jac/43.2.277

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activities of ampicillin, amoxycillin-clavulanic acid, gentamicin, tetracycline, nalidixic acid, ciprofloxacin, pefloxacin and trovafloxacin against 207 consecutive clinical isolates of Escherichia coli were determined. Fifty-six (27.3%) isolates were haemolytic. The percentages of resistance to quinolones and tetracycline, but not to other agents, among haemolytic isolates were significantly lower (P < 0.05) than among non-haemolytic isolates. Ciprofloxacin-resistant mutants obtained from ciprofloxacin-susceptible haemolytic isolates still produced haemolysis. It is concluded that most quinolone-resistant clinical isolates of E. coli are non-haemolytic, although haemolysis is produced by quinolone-resistant mutants derived from haemolytic quinolone-susceptible strains.

引用

页码：277 / 279

页数：3

共 10 条

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