Protease-activated receptor-2 (PAR2) in cardiovascular system

被引：23

作者：

Bucci, M ^{[1
]}

Roviezzo, F ^{[1
]}

Cirino, G ^{[1
]}

机构：

[1] Univ Naples Federico II, Fac Pharm, Dept Expt Pharmacol, I-80131 Naples, Italy

来源：

VASCULAR PHARMACOLOGY | 2005年 / 43卷 / 04期

关键词：

PAR(2); vascular reactivity; endothelium; G-protein;

D O I：

10.1016/j.vph.2005.07.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vascular system is constituted by a complex and articulate network, e.g. arteries, arterioles, venules and veins, that requires a high degree of coordination between different elemental cell types. Protemase-activated receptors (PARs) constitute a recent described family of 7-transtrembrane G protein-coupled receptors that are activated by proteolysis. In recent years several evidence have been accumulated for an involvement of this receptor in the response to endothelial injury in vitro and in vivo experimental settings suggesting a role for PAR(2) in the pathophysiology of cardiovascular system. This review will deal with the role of PAR(2) receptor in the cardiovascular system analyzing both in vivo and in vitro published data. In particular this review will deal with the role of this receptor in vascular reactivity, ischemia/reperfusion injury, coronary atherosclerotic lesions and angiogenesis. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：247 / 253

页数：7

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