Diffusion imaging for evaluation of tumor therapies in preclinical animal models

被引：91

作者：

Moffat, BA

Hall, DE

Stojanovska, J

McConville, PJ

Moody, JB

Chenevert, TL

Rehemtulla, A

Ross, BD

机构：

[1] Univ Michigan, Ctr Mol Imaging, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[3] Mol Imaging Res, Ann Arbor, MI 48104 USA

来源：

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE | 2004年 / 17卷 / 3-6期

关键词：

apparent diffusion coefficient; ADC; diffusion; tumor; therapeutic efficacy; MRI; NMR;

D O I：

10.1007/s10334-004-0079-z

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.

引用

页码：249 / 259

页数：11

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