Animal models of bipolar disorder

被引:56
作者
Kato, Tadafumi [1 ]
Kubota, Mie [1 ]
Kasahara, Takaoki [1 ]
机构
[1] RIKEN, Lab Mol Dynam Mental Disorders, Brain Sci Inst, Wako, Saitama 3510198, Japan
关键词
bipolar disorder; animal model; Transgenic mice; calcium; mitochondrial DNA; polymerase gamma (POLG); cyclophilin D; cyclosporin A; lithium; circadian rhythm; wheel running;
D O I
10.1016/j.neubiorev.2007.03.003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Animal models of human diseases should meet three sets of criteria: construct validity, face validity, and predictive validity. To date, several putative animal models of bipolar disorder have been reported. They are classified into various categories: pharmacological models, nutritional models, environmental models, and genetic models. None of them, however, totally fulfills the three validity criteria., and thus may not be useful for drug development. Mounting evidence suggests that mitochondrial dysfunction has a role in bipolar disorder. To test whether accumulation of mtDNA deletions in the brain can cause bipolar disorder, we generated transgenic mice with neuron-specific expression of mutant Polg (D181A). These mice showed altered diurnal activity rhythm and periodic activity change associated with the estrous cycle. These phenotypes were worsened by administration of a tricyclic antidepressant, but improved after lithium treatment. This mouse model of bipolar disorder potentially fulfills the three validity criteria, and therefore might be used for future drug development studies. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:832 / 842
页数:11
相关论文
共 107 条
[1]   The effects of lithium on a potential cycling model of bipolar disorder [J].
Antelman, SM ;
Caggiula, AR ;
Kucinski, BJ ;
Fowler, H ;
Gershon, S ;
Edwards, DJ ;
Austin, MC ;
Stiller, R ;
Kiss, S ;
Kocan, D .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1998, 22 (03) :495-510
[2]   Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania [J].
Arban, R ;
Maraia, G ;
Brackenborough, K ;
Winyard, L ;
Wilson, A ;
Gerrard, P ;
Large, C .
BEHAVIOURAL BRAIN RESEARCH, 2005, 158 (01) :123-132
[3]   DEFECTIVE BRAIN ENERGY-METABOLISM SHOWN BY INVIVO P-31 MR SPECTROSCOPY IN 28 PATIENTS WITH MITOCHONDRIAL CYTOPATHIES [J].
BARBIROLI, B ;
MONTAGNA, P ;
MARTINELLI, P ;
LODI, R ;
IOTTI, S ;
CORTELLI, P ;
FUNICELLO, R ;
ZANIOL, P .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (03) :469-474
[4]   EFFECTS OF LITHIUM ON AN AMPHETAMINE ANIMAL-MODEL OF BIPOLAR DISORDER [J].
CAPPELIEZ, P ;
MOORE, E .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1990, 14 (03) :347-358
[5]   The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS [J].
Chen, G ;
Zeng, WZ ;
Yuan, PX ;
Huang, LD ;
Jiang, YM ;
Zhao, ZH ;
Manji, HK .
JOURNAL OF NEUROCHEMISTRY, 1999, 72 (02) :879-882
[6]   The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3 [J].
Chen, G ;
Huang, LD ;
Jiang, YM ;
Manji, HK .
JOURNAL OF NEUROCHEMISTRY, 1999, 72 (03) :1327-1330
[7]   Brain metabolic alterations in medication-free patients with bipolar disorder [J].
Dager, SR ;
Friedman, SD ;
Parow, A ;
Demopulos, C ;
Stoll, AL ;
Lyoo, IK ;
Dunner, DL ;
Renshaw, PF .
ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (05) :450-458
[8]   Open field is more sensitive than automated activity monitor in documenting ouabain-induced hyperlocomotion in the development of an animal model for bipolar illness [J].
Decker, S ;
Grider, G ;
Cobb, M ;
Li, XP ;
Huff, MO ;
El-Mallakh, RS ;
Levy, RS .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2000, 24 (03) :455-462
[9]  
DEICKEN RF, 1995, AM J PSYCHIAT, V152, P915
[10]   One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats [J].
DeMar, JC ;
Ma, KZ ;
Bell, JM ;
Igarashi, M ;
Greenstein, D ;
Rapoport, SI .
JOURNAL OF LIPID RESEARCH, 2006, 47 (01) :172-180