The TOC complex: Preprotein gateway to the chloroplast

被引：55

作者：

Andres, Charles ^{[1
]}

Agne, Birgit ^{[1
]}

Kessler, Felix ^{[1
]}

机构：

[1] Univ Neuchatel, Lab Physiol Vegetale, Inst Biol, CH-2009 Neuchatel, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2010年 / 1803卷 / 06期

关键词：

Protein targeting; Chloroplast; Preprotein; Translocon; OUTER ENVELOPE MEMBRANE; PROTEIN IMPORT APPARATUS; PRECURSOR PROTEINS; TRANSIT PEPTIDES; GTP-BINDING; ARABIDOPSIS-THALIANA; INTERMEMBRANE SPACE; CHANNEL TOC75; TRANSLOCATION COMPLEXES; MOLECULAR CHAPERONE;

D O I：

10.1016/j.bbamcr.2010.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photosynthetic eukaryotes strongly depend on chloroplast metabolic pathways Most if not all Involve nuclear encoded proteins. These are synthesized as cytosolic preproteins with N-terminal, cleavable targeting sequences (transit peptide). Preproteins are imported by a major pathway composed of two proteins complexes: TOC and TIC (Translocon of the Outer and Inner membranes of the Chloroplasts, respectively). These selectively recognize the preproteins and facilitate their transport across the chloroplast envelope The TOC core complex consists of three types of components, each belonging to a small family. Toc34, Toc75 and Toc159. 'Toc34 and Toc159 isoforms represent a subfamily of the GTPase superfamily The members of the Toc34 and Toc159 subfamily act as GTP-dependent receptors at the chloroplast surface and distinct members of each occur in defined, substrate-specific TOC complexes. Toc75, a member of the Omp85 family, is conserved from prokaryotes and functions as the unique protein-conducting channel at the outer membrane In this review we will describe the current state of knowledge regarding the composition and function of the TOC complex (C) 2010 Elsevier B.V All rights reserved

引用

页码：715 / 723

页数：9

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