Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

被引：37

作者：

Kourtis, Athena P.

Jamieson, Denise J.

de Vincenzi, Isabelle

Taylor, Allan

Thigpen, Michael C.

Dao, Halima

Farley, Timothy

Fowler, Mary Glenn

机构：

[1] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Div HIV AIDS Prevent Surveillance & Epidemiol, Atlanta, GA USA

[2] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Global AIDS Progam, Atlanta, GA USA

[3] World Hlth Org, Dept Reprod Hlth & Res, Geneva, Switzerland

[4] Johns Hopkins Univ, Makerere Univ Res Collaborat, Kampala, Uganda

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2007年 / 197卷 / 03期

关键词：

breast milk; human immunodeficiency virus; infant; prevention; transmission;

D O I：

10.1016/j.ajog.2007.03.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Breastfeeding accounts for up to half of all infant human immunodeficiency virus (HIV) infections worldwide and carries an estimated transmission risk of about 15% when continued into the second year of life. Because replacement feeding is not safely available, culturally acceptable, or affordable in many parts of the world and because breastfeeding provides protection against other causes of infant mortality, approaches that reduce breastfeeding mother-to child transmission of HIV are being explored. These include exclusive breastfeeding for the infant's first few months of life followed by rapid weaning, treatments of expressed milk to inactivate the virus, and antiretroviral prophylaxis taken by the infant or mother during breastfeeding, which are strategies currently being tested in clinical trials. Passive (antibodies) and active (vaccine) immunoprophylaxis will also soon begin to be tested. This paper focuses on current and planned research on strategies to prevent breastfeeding transmission of HIV.

引用

页码：S113 / S122

页数：10

共 85 条

[1]

[Anonymous], 2003, HIV INF FEED GUID DE

[2] Compartmentalization of HIV-1 between breast milk and blood of HIV-infected mothers [J].

Becquart, P ;

Chomont, N ;

Roques, P ;

Ayouba, A ;

Kazatchkine, MD ;

Bélec, L ;

Hocini, H .

VIROLOGY, 2002, 300 (01) :109-117

[3] Compartmentalization of the IgG immune response to HIV-1 in breast milk [J].

Becquart, P ;

Hocini, H ;

Garin, B ;

Sépou, A ;

Kazatchkine, MD ;

Bélec, L .

AIDS, 1999, 13 (11) :1323-1331

[4] HUMAN BREAST-MILK LYMPHOCYTES-T DISPLAY THE PHENOTYPE AND FUNCTIONAL-CHARACTERISTICS OF MEMORY T-CELLS [J].

BERTOTTO, A ;

GERLI, R ;

FABIETTI, G ;

CRUPI, S ;

ARCANGELI, C ;

SCALISE, F ;

VACCARO, R .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (08) :1877-1880

[5] Chloroquine accumulates in breast-milk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1 [J].

Boelaert, JR ;

Yaro, S ;

Augustijns, P ;

Meda, N ;

Schneider, YJ ;

Schols, D ;

Mols, R ;

De Laere, EA ;

Van de Perre, P .

AIDS, 2001, 15 (16) :2205-2207

[6] Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine [J].

Chung, MH ;

Kiarie, JN ;

Richardson, BA ;

Lehman, DA ;

Overbaugh, J ;

John-Stewart, GC .

AIDS, 2005, 19 (13) :1415-1422

[7] Prevention and treatment of perinatal HIV-1 infection in the developing world [J].

Coovadia, HM .

CURRENT OPINION IN INFECTIOUS DISEASES, 2000, 13 (03) :247-251

[8] Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study [J].

Coutsoudis, A ;

Pillay, K ;

Spooner, E ;

Kuhn, L ;

Coovadia, HM .

LANCET, 1999, 354 (9177) :471-476

[9] Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child HIV-1 transmission in Durban, South Africa [J].

Coutsoudis, A ;

Pillay, K ;

Spooner, E ;

Kuhn, L ;

Coovadia, HM .

AIDS, 1999, 13 (12) :1517-1524

[10]

Coutsoudis A, 2004, J INFECT DIS, V189, P2154, DOI 10.1086/420834

← 1 2 3 4 5 6 7 8 9 →