A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents

被引：48

作者：

Liu, Q ^{[1
]}

Luedtke, NW ^{[1
]}

Tor, Y ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)02289-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and highly efficient synthesis of monosubstituted ureas is described. The reaction of an amine with 4-nitrophenyl-N-benzylcarbamate, followed by hydrogenolysis, provides the corresponding urea in high yield and purity. This carbamate can also be employed for the derivatization of water-soluble polyamines (e.g. aminoglycoside antibiotics), while other reagents (e.g, benzylisocyanate) fail to give the desired products in any significant yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1445 / 1447

页数：3

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