Influenza epidemiology and immunization during pregnancy: Final report of a World Health Organization working group

被引：79

作者：

Fell, Deshayne B. ^{[1
,2
]}

Azziz-Baumgartner, Eduardo ^{[3
]}

Baker, Michael G. ^{[4
]}

Batra, Maneesh ^{[5
]}

Beaute, Julien ^{[6
]}

Beutels, Philippe ^{[7
]}

Bhat, Niranjan ^{[8
]}

Bhutta, Zulfiqar A. ^{[9
,10
]}

Cohen, Cheryl ^{[11
,12
]}

De Mucio, Bremen ^{[13
]}

Gessner, Bradford D. ^{[14
]}

Gravett, Michael G. ^{[15
]}

Katz, Mark A. ^{[16
,17
,18
]}

Knight, Marian ^{[19
]}

Lee, Vernon J. ^{[20
]}

Loeb, Mark ^{[21
]}

Luteijn, Johannes M. ^{[22
]}

Marshall, Helen ^{[23
,24
,25
]}

Nair, Harish ^{[26
]}

Pottie, Kevin ^{[27
]}

Salam, Rehana A. ^{[28
,29
]}

Savitz, David A. ^{[30
,31
,32
]}

Serruya, Suzanne J. ^{[13
]}

Skidmore, Becky

Ortiz, Justin R. ^{[33
]}

机构：

[1] Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada

[2] Univ Ottawa, CHEO, Res Inst, Ottawa, ON, Canada

[3] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA

[4] Univ Otago, Dept Publ Hlth, Wellington, New Zealand

[5] Univ Washington, Sch Med, Dept Pediat Neonatol, Seattle, WA 98195 USA

[6] European Ctr Dis Prevent & Control ECDC, Stockholm, Sweden

[7] Univ Antwerp, CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, Antwerp, Belgium

[8] PATH, Ctr Vaccine Innovat & Access, Seattle, WA USA

[9] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada

[10] Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan

[11] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa

[12] Univ Witwatersrand, Sch Publ Hlth, Johannesburg, South Africa

[13] Women & Reprod Hlth Panamerican Hlth Org, Latin Amer Ctr Perinatol, Montevideo, Uruguay

[14] Agence Med Prevent, Paris, France

[15] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[16] Ben Gurion Univ Negev, Med Sch Int Hlth, Beer Sheva, Israel

[17] Ben Gurion Univ Negev, Dept Hlth Syst Management, Beer Sheva, Israel

[18] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA

[19] Univ Oxford, Natl Perinatal Epidemiol Unit, Oxford, England

[20] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[21] McMaster Univ, Inst Infect Dis Res, Hamilton, ON, Canada

[22] Queen Mary Univ London, London, England

[23] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia

[24] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia

[25] Womens & Childrens Hlth Network, Adelaide, SA, Australia

[26] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

[27] Univ Ottawa, Dept Family Med, Ottawa, ON, Canada

[28] Univ Adelaide, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[29] Aga Khan Univ, Div Women & Child Hlth, Karachi, Pakistan

[30] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA

[31] Brown Univ, Dept Obstet, Providence, RI 02912 USA

[32] Brown Univ, Dept Gynecol, Providence, RI 02912 USA

[33] WHO, Initiat Vaccine Res, Geneva, Switzerland

来源：

VACCINE | 2017年 / 35卷 / 43期

关键词：

Influenza; Immunization; Pregnancy; Infants; RESPIRATORY SYNCYTIAL VIRUS; MATERNAL INFLUENZA; PANDEMIC INFLUENZA; FETAL-DEATH; YOUNG-CHILDREN; UNITED-STATES; SOUTH-AFRICA; VACCINATION; INFECTION; WOMEN;

D O I：

10.1016/j.vaccine.2017.08.037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

From 2014 to 2017, the World Health Organization convened a working group to evaluate influenza disease burden and vaccine efficacy to inform estimates of maternal influenza immunization program impact. The group evaluated existing systematic reviews and relevant primary studies, and conducted four new systematic reviews. There was strong evidence that maternal influenza immunization prevented influenza illness in pregnant women and their infants, although data on severe illness prevention were lacking. The limited number of studies reporting influenza incidence in pregnant women and infants under six months had highly variable estimates and underrepresented low- and middle-income countries. The evidence that maternal influenza immunization reduces the risk of adverse birth outcomes was conflicting, and many observational studies were subject to substantial bias. The lack of scientific clarity regarding disease burden or magnitude of vaccine efficacy against severe illness poses challenges for robust estimation of the potential impact of maternal influenza immunization programs. (C) 2017 The Authors. Published by Elsevier Ltd.

引用

页码：5738 / 5750

页数：13

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