8-O-cinnamoylneoline, a new alkaloid from the flower buds of Aconitum carmichaeli and its toxic and analgesic activities

被引：21

作者：

Taki, M ^{[1
]}

Niitu, K ^{[1
]}

Omiya, Y ^{[1
]}

Noguchi, M ^{[1
]}

Fukuchi, M ^{[1
]}

Aburada, M ^{[1
]}

Okada, M ^{[1
]}

机构：

[1] Tsumura & Co, Tsuruma Res Inst, Ami, Ibaraki 3001192, Japan

来源：

PLANTA MEDICA | 2003年 / 69卷 / 09期

关键词：

Aconitum carmichaeli; Ranunculaceae; 8-O-cinnamoylneoline; analgesic effect; toxicity;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

From flower buds of Aconitum carmichaeli Debx., a new alkaloid, 8-O-cinnamoylneoline, was isolated. The structure of the new alkaloid was determined by spectral analysis, and the alkaloid was examined for its toxic and analgesic activities. Its LD50 value was 11.89 mg/kg (s.c.) in mice: the toxicity was 1/30 times that of me-saconitine and 20 times that of benzoylmesaconine. Its ED50 value was 0.86 mg/kg (s.c.) in mice using the tail pressure method: its analgesic effect was 1/40 times that of mesaconitine and 45 times that of benzoylmesaconine. Its safety margin ( = LD50/ ED50) was higher than that of benzoylmesaconine but lower than that of mesaconitine.

引用

页码：800 / 803

页数：4

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