Stereoselective synthesis of 3-substituted phtalides via asymmetric transfer hydrogenation using well-defined ruthenium catalysts under neutral conditions

被引：57

作者：

Everaere, K ^{[1
]}

Scheffler, JL ^{[1
]}

Mortreux, A ^{[1
]}

Carpentier, JF ^{[1
]}

机构：

[1] ENSCL, Grp Chim Organ Appl, CNRS, Lab Catalyse Lille, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

asymmetric transfer hydrogenation; chiral phtalides; chiral Ru catalysts;

D O I：

10.1016/S0040-4039(01)00076-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric transfer hydrogenation of methyl 2-acylbenzoates and 2-propyl 3-acetylpyridine- 2-carboxylate in 2-propanol, in the absence of base, with presynthesized Ru-{beta -amino alcohol) or Ru-{TsDPEN) true catalysts provides 3-alkylphtalides in high yields and 92-97% ee. The procedure is, however, not as efficient for the preparation of optically active 3-phenylphtalide. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1899 / 1901

页数：3

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