Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

被引：228

作者：

Howells, David W. ^{[1
,2
]}

Porritt, Michelle J. ^{[1
,2
]}

Rewell, Sarah S. J. ^{[1
,2
]}

O'Collins, Victoria ^{[1
,2
]}

Sena, Emily S. ^{[3
]}

van der Worp, H. Bart ^{[4
]}

Traystman, Richard J. ^{[5
]}

Macleod, Malcolm R. ^{[3
]}

机构：

[1] Natl Stroke Res Inst, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[3] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[4] Univ Med Ctr, Dept Neurol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands

[5] Univ Colorado Denver, Aurora, CO USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 08期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

animal models; diabetes; hypertension; physiologic control; stroke; vascular variability; SPONTANEOUSLY HYPERTENSIVE-RATS; TISSUE-PLASMINOGEN-ACTIVATOR; INTRALUMINAL THREAD MODEL; CAROTID-ARTERY OCCLUSION; LASER-DOPPLER FLOWMETRY; BRAIN-DAMAGE; BLOOD-FLOW; INFARCT SIZE; SPONTANEOUS HYPERTHERMIA; THROMBOEMBOLIC STROKE;

D O I：

10.1038/jcbfm.2010.66

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1412-1431; doi: 10.1038/jcbfm.2010.66; published online 19 May 2010

引用

页码：1412 / 1431

页数：20

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