Role of inflammation in the aging bones

被引：101

作者：

Abdelmagid, Samir M. ^{[1
]}

Barbe, Mary F. ^{[3
]}

Safadi, Fayez F. ^{[1
,2
]}

机构：

[1] Northeast Ohio Med Univ NEOMED, Dept Anat & Neurobiol, Sch Med, Rootstown, OH 44272 USA

[2] Kent State Univ, Sch Biomed Sci, Kent, OH 44240 USA

[3] Temple Univ, Dept Anat & Cell Biol, Sch Med, Philadelphia, PA 19140 USA

来源：

LIFE SCIENCES | 2015年 / 123卷

关键词：

Aging; Inflammation; Macrophages; Osteoblasts; Osteoclasts; Bone adaptation; Bone resorption; MESENCHYMAL STEM-CELLS; NECROSIS-FACTOR-ALPHA; ALKALINE-PHOSPHATASE ACTIVITY; OSTEOCLAST FORMATION; INHIBITORY FACTOR; RAT MODEL; OSTEOBLAST DIFFERENTIATION; TNF-ALPHA; RHEUMATOID-ARTHRITIS; HUMAN-MELANOMA;

D O I：

10.1016/j.lfs.2014.11.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to inherent changes in mesenchymal stem cell (MSC) differentiation, resulting in impaired osteoblastogenesis. Also, the pro-inflammatory cytokines increase with aging, leading to enhanced myelopoiesis and osteoclastogenesis. Bone marrow macrophages (BMMs) play pivotal roles in osteoblast differentiation, the maintenance of hematopoietic stem cells (HSCs), and subsequent bone repair. However, during aging, little is known about the role of macrophages in the differentiation and function of MSC and HSC. Aged mammals have higher circulating pro-inflammatory cytokines than young adults, supporting the hypothesis of increased inflammation with aging. This review will aid in the understanding of the potential role(s) of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in differentiation and function of osteoblasts and osteoclasts in relation to aging. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：25 / 34

页数：10

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