Viral correlates of HIV-1 disease

被引：5

作者：

Anastassopoulou, CG

Kostrikis, LG

机构：

[1] Univ Cyprus, Dept Biol Sci, CY-1678 Nicosia, Cyprus

[2] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

来源：

CURRENT HIV RESEARCH | 2005年 / 3卷 / 02期

关键词：

subtype; clade; biological phenotype; tropism; attenuation; transmission; disease progression;

D O I：

10.2174/1570162053506946

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

xThe transmission of HIV and the progression of HIV disease are influenced not only by a large number of human host factors, but also by certain correlates of the ever fluctuating virus quasispecies. The present review article aims at providing the current state of knowledge as well as an in-depth critical discussion of recent developments on the potential effects of HIV subtype, phenotype and attenuation on HIV disease. Despite the extensive research, several questions regarding the precise role that each of these correlates plays in human AIDS pathogenesis remain unanswered. Unraveling these roles is expected to aid the continued quest for truly effective antiretroviral drug regimens and preventive vaccines.

引用

收藏

页码：113 / 132

页数：20

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