Control of orientation of rat Schwann cells using an 8-T static magnetic field

被引：105

作者：

Eguchi, Y ^{[1
]}

Ogiue-Ikeda, M ^{[1
]}

Ueno, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Biomed Engn, Bunkyo Ku, Tokyo 1130033, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 351卷 / 02期

关键词：

static magnetic field; magnetic orientation; magnetically aligned collagen; Schwann cell; Wallerian degeneration; nerve regeneration;

D O I：

10.1016/S0304-3940(03)00719-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Schwann. cells aid in neuronal regeneration in the peripheral nervous system via guiding the regrowth of axons. In this study, we investigated the magnetic orientation of Schwann cells, and of a mixture of Schwann cells and collagen, after an 8-tesla magnetic field exposure. We obtained cultured Schwann cells from dissected sciatic nerves of neonatal rats. After 60 h of magnetic field exposure, Schwann cells oriented parallel to the magnetic fields. In contrast, the mixture of Schwann cells and collagen, Schwann cells oriented in the direction perpendicular to the magnetic field after 2 h of magnetic field exposure. In this case, Schwann cells aligned along the collagen fiber oriented by magnetic fields. The magnetic control of Schwann cell alignment is useful in medical engineering applications such as nerve regeneration. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 132

页数：3

共 10 条

[1]

Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration [J].