Caged O-phosphorothioyl amino acids as building blocks for Fmoc-based solid phase peptide synthesis

被引：8

作者：

Aemissegger, Andreas ^{[1
]}

Carrigan, Christina N. ^{[1
]}

Imperiali, Barbara ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON | 2007年 / 63卷 / 27期

关键词：

D O I：

10.1016/j.tet.2007.03.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-(2-nitrophenylethyl) caged O-phosphorothioylserine, -threonine, and -tyrosine derivatives is reported. These amino acid building blocks can be directly incorporated into peptides by Fmoc-based solid phase synthesis as their pentafluorophenyl esters or as symmetric anhydrides. Upon irradiation with UV light, the thiophosphate group, representing a hydrolysis resistant phosphate analog, is revealed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6185 / 6190

页数：6

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