Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training

被引：58

作者：

Kemi, Ole Johan ^{[1
,2
]}

Ceci, Marcello ^{[4
]}

Condorelli, Gianluigi ^{[4
,5
]}

Smith, Godfrey L. ^{[1
]}

Wisloff, Ulrik ^{[2
,3
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Norwegian Univ Sci & Technol, Fac Med, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway

[3] St Olavs Hosp, Dept Cardiol, Trondheim, Norway

[4] IRCCS Multimed, Milan, Italy

[5] Univ Calif San Diego, Dept Med, Div Cardiol, La Jolla, CA 92093 USA

来源：

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2008年 / 15卷 / 02期

关键词：

calcium; exercise; myocardium; sarcoplasmic reticulum Ca2+ ATPase;

D O I：

10.1097/HJR.0b013e3282efd4e0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Reduced activity of the sarcoplasmic reticulum Ca2+ ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca2+-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training. Methods SERCA-2a function was assessed by sarcoplasmic reticulum Ca2+ uptake in cardiornyocytes with other Ca2+ uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls. Results We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca2+ uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio. Conclusion Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca2+-handling improves after exercise training.

引用

页码：145 / 148

页数：4

共 12 条

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