Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barre syndrome

被引：27

作者：

Koga, M ^{[1
]}

Tatsumoto, M ^{[1
]}

Yuki, N ^{[1
]}

Hirata, K ^{[1
]}

机构：

[1] Dokkyo Univ, Sch Med, Dept Neurol, Shimotsuga, Tochigi 3210293, Japan

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2001年 / 71卷 / 01期

关键词：

Guillain-Barre syndrome; anti-GM1; antibody; cross reactivity;

D O I：

10.1136/jnnp.71.1.123

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The cross reactivity of anti-GM1 IgG antibody with various gangliosides and asialo-GM1 in serum samples from 27 patients with Guillain-Barre syndrome was investigated. An enzyme linked immunosorbent assay (ELISA) absorption study showed that anti-GM1 IgG antibody cross reacted with asialo-GM1 in 52% of the patients, GM1b in 41%, GD1b in 22%, and GalNAc-GD1a in 19%, and that it did not cross react with GM2, GT1b, or GQ1b. The antibody that cross reacted with GD1b was associated with a high frequency of cranial nerve involvement and negative Campylobacter jejuni serology. Anti-GM1 IgG antibody has a broad range of cross reactivity which may contribute to various clinical variations of Guillain-Barre syndrome.

引用

页码：123 / 124

页数：2

共 10 条

[1]

ASSESSMENT OF CURRENT DIAGNOSTIC-CRITERIA FOR GUILLAIN-BARRE-SYNDROME [J].

ASBURY, AK ;

CORNBLATH, DR .

ANNALS OF NEUROLOGY, 1990, 27 :S21-S24

[2]

Autoimmune ataxic neuropathies (sensory ganglionopathies): Are glycolipids the responsible autoantigens? [J].

Dalakas, MC ;

Quarles, RH .

ANNALS OF NEUROLOGY, 1996, 39 (04) :419-422

[3]

HARTUNG HP, 1995, MUSCLE NERVE, V18, P137, DOI 10.1002/mus.880180202

[4]

Campylobacter jejuni infections and anti-GM1 antibodies in Guillain-Barre syndrome [J].

Jacobs, BC ;

vanDoorn, PA ;

Schmitz, PIM ;

TioGillen, AP ;

Herbrink, P ;

Visser, LH ;

Hooijkaas, H ;

vanderMeche, FGA .

ANNALS OF NEUROLOGY, 1996, 40 (02) :181-187

[5]

Is IgG anti-GT1a antibody associated with pharyngeal-cervical-brachial weakness or oropharyngeal palsy in Guillain-Barre syndrome? [J].

Koga, M ;

Yuki, N ;

Ariga, T ;

Morimatsu, M ;

Hirata, K .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 86 (01) :74-79

[6]

IgG anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barre syndrome [J].

Kuwabara, S ;

Yuki, N ;

Koga, M ;

Hattori, T ;

Matsuura, D ;

Miyake, M ;

Noda, M .

ANNALS OF NEUROLOGY, 1998, 44 (02) :202-208

[7]

CAMPYLOBACTER-JEJUNI INFECTION AND GUILLAIN-BARRE-SYNDROME [J].

REES, JH ;

SOUDAIN, SE ;

GREGSON, NA ;

HUGHES, RAC .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (21) :1374-1379

[8]

ANTIGANGLIOSIDE GM(1) ANTIBODIES IN GUILLAIN-BARRE-SYNDROME AND THEIR RELATIONSHIP TO CAMPYLOBACTER-JEJUNI INFECTION [J].

REES, JH ;

GREGSON, NA ;

HUGHES, RAC .

ANNALS OF NEUROLOGY, 1995, 38 (05) :809-816

[9]

Fine specificity of anti-GQ1b IgG and clinical features [J].

Susuki, K ;

Yuki, N ;

Hirata, K .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2001, 185 (01) :5-9

[10]

TATSUMOTO M, 1998, MUSCLE NERVE, V7, pS211

← 1 →