Marrying immunotherapy with chemotherapy: why say IDO?

被引：90

作者：

Muller, AJ ^{[1
]}

Prendergast, GC ^{[1
]}

机构：

[1] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

来源：

CANCER RESEARCH | 2005年 / 65卷 / 18期

关键词：

D O I：

10.1158/0008-5472.CAN-05-2213

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A recent study now shows how small-molecule inhibitors of IDO can be used to leverage the efficacy of traditional chemotherapeutic drugs that are used to treat cancer in the clinic. By promoting antitumor immune responses in combination with cytotoxic chemotherapy, IDO inhibitors may offer a drug-based strategy to more effectively attack systemic cancer.

引用

页码：8065 / 8068

页数：4

共 35 条

[1] Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
Baban, B
Chandler, P
McCool, D
Marshall, B
Munn, DH
Mellor, AL
[J]. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2004, 61 (02) : 67 - 77
[2] Cytoplasmic transport of Stat3 by receptor-mediated endocytosis
Bild, AH
Turkson, J
Jove, R
[J]. EMBO JOURNAL, 2002, 21 (13) : 3255 - 3263
[3] METABOLISM OF TRYPTOPHAN .2. METABOLISM OF TRYPTOPHAN IN PATIENTS SUFFERING FROM CANCER OF THE BLADDER
BOYLAND, E
WILLIAMS, DC
[J]. BIOCHEMICAL JOURNAL, 1956, 64 (03) : 578 - 582
[4] The immunobiology of cancer immunosurveillance and immunoediting
Dunn, GP
Old, LJ
Schreiber, RD
[J]. IMMUNITY, 2004, 21 (02) : 137 - 148
[5] Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms
Elliott, K
Sakamuro, D
Basu, A
Du, W
Wunner, W
Staller, P
Gaubatz, S
Zhang, H
Prochownik, E
Eilers, M
Prendergast, GC
[J]. ONCOGENE, 1999, 18 (24) : 3564 - 3573
[6] CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
Erdman, SE
Sohn, JJ
Rao, VP
Nambiar, PR
Ge, ZM
Fox, JG
Schauer, DB
[J]. CANCER RESEARCH, 2005, 65 (10) : 3998 - 4004
[7] T cell apoptosis by tryptophan catabolism
Fallarino, I
Grohmann, U
Vacca, C
Bianchi, R
Orabona, C
Spreca, A
Fioretti, MC
Puccetti, P
[J]. CELL DEATH AND DIFFERENTIATION, 2002, 9 (10) : 1069 - 1077
[8] Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
Friberg, M
Jennings, R
Alsarraj, M
Dessureault, S
Cantor, A
Extermann, M
Mellor, AL
Munn, DH
Antonia, SJ
[J]. INTERNATIONAL JOURNAL OF CANCER, 2002, 101 (02) : 151 - 155
[9] Ge K, 2000, INT J CANCER, V86, P155, DOI 10.1002/(SICI)1097-0215(20000415)86:2<155::AID-IJC2>3.0.CO
[10] 2-M

← 1 2 3 4 →