The dynamin superfamily: Universal membrane tubulation and fission molecules?

被引：1097

作者：

Praefcke, GJK ^{[1
]}

McMahon, HT ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 02期

关键词：

D O I：

10.1038/nrm1313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dynamins are large GTPases that belong to a protein superfamily that, in eukaryotic cells, includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins. They are involved in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance. With sequenced genomes from Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, yeast species and Arabidopsis thaliana, we now have a complete picture of the members of the dynamin superfamily from different organisms. Here, we review the superfamily of dynamins and their related proteins, and propose that a common mechanism leading to membrane tubulation and/or fission could encompass their many varied functions.

引用

收藏

页码：133 / 147

页数：15

相关论文

共 145 条

[1] The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum [J].

Accola, MA ;

Huang, B ;

Al Masri, A ;

McNiven, MA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21829-21835

[2]

Achiriloaie M, 1999, MOL CELL BIOL, V19, P1410

[3] OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 [J].

Alexander, C ;

Votruba, M ;

Pesch, UEA ;

Thiselton, DL ;

Mayer, S ;

Moore, A ;

Rodriguez, M ;

Kellner, U ;

Leo-Kottler, B ;

Auburger, G ;

Bhattacharya, SS ;

Wissinger, B .

NATURE GENETICS, 2000, 26 (02) :211-215

[4] Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus [J].

Anderson, SL ;

Carton, JM ;

Lou, J ;

Xing, L ;

Rubin, BY .

VIROLOGY, 1999, 256 (01) :8-14

[5] A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division [J].

Arimura, S ;

Tsutsumi, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5727-5731

[6] GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein alpha subunits [J].

Berman, DM ;

Wilkie, TM ;

Gilman, AG .

CELL, 1996, 86 (03) :445-452

[7] The mechanism of GTP hydrolysis by dynamin II: A transient kinetic study [J].

Binns, DD ;

Helms, MK ;

Barylko, B ;

Davis, CT ;

Jameson, DM ;

Albanesi, JP ;

Eccleston, JF .

BIOCHEMISTRY, 2000, 39 (24) :7188-7196

[8] THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].

BOURNE, HR ;

SANDERS, DA ;

MCCORMICK, F .

NATURE, 1990, 348 (6297) :125-132

[9] Differential distribution of dynamin isoforms in mammalian cells [J].

Cao, H ;

Garcia, F ;

McNiven, MA .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (09) :2595-2609

[10] Dynamin assembles into spirals under physiological salt conditions upon the addition of GDP and gamma-phosphate analogues [J].

Carr, JF ;

Hinshaw, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :28030-28035

← 1 2 3 4 5 6 7 8 9 10 →