Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth

被引：39

作者：

Ji, J ^{[1
]}

Zhu, HG ^{[1
]}

Shen, JC ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

来源：

BIOMATERIALS | 2004年 / 25卷 / 10期

基金：

中国国家自然科学基金;

关键词：

poly(DL-lactic acid) (PDL-LA); PEO-PPO-PEO amphiphilic copolymer; amino acid; tissue engineering; chondrocyte;

D O I：

10.1016/j.biomaterials.2003.08.031

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By blending the PDL-LA with the ligand-tethered PEO-PPO-PEO derivatives, the surface of modified PDL-LA film was investigated by ATR-FTIR, XPS and contact angle. The chondrocytes test on different PDL-LA films indicated that the PEO-PPO-PEO amino acid and RGD derivatives modified PDL-LA films could promote chondrocyte attachment and growth. This simple surface treatment method may have potentials for tissue engineering and other biomedical applications. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1859 / 1867

页数：9

共 37 条

[1]

Synthesis and properties of poly(lactic acid) [J].