Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：63

作者：

Britton, Julie A. ^{[1
,2
]}

Khan, Aneire E. ^{[1
]}

Rohrmann, Sabine ^{[3
]}

Becker, Nikolaus ^{[3
]}

Linseisen, Jakob ^{[3
]}

Nieters, Alexandra ^{[3
]}

Kaaks, Rudolf ^{[3
]}

Tjonneland, Anne ^{[4
]}

Halkjaer, Jytte ^{[4
]}

Severinsen, Marianne Tang ^{[5
]}

Overvad, Kim ^{[6
]}

Pischon, Tobias ^{[7
]}

Boeing, Heiner ^{[7
]}

Trichopoulou, Antonia ^{[8
]}

Kalapothaki, Victoria ^{[8
]}

Trichopoulos, Dimitrios ^{[9
]}

Mattiello, Amalia ^{[10
]}

Tagliabue, Giovanna ^{[11
,12
]}

Sacerdote, Carlotta ^{[13
]}

Peeters, Petra H. M. ^{[14
]}

Bueno-de-Mesquita, H. Bas ^{[15
]}

Ardanaz, Eva ^{[16
]}

Navarro, Carmen ^{[17
]}

Jakszyn, Paula ^{[18
]}

Altzibar, Jone M. ^{[19
]}

Hallmans, Goran ^{[20
]}

Malmer, Beatrice ^{[21
]}

Berglund, Goran ^{[22
]}

Manjer, Jonas ^{[23
]}

Allen, Naomi ^{[24
]}

Key, Timothy ^{[24
]}

Bingham, Sheila ^{[25
]}

Besson, Herve ^{[26
]}

Ferrari, Pietro ^{[27
]}

Jenab, Mazda ^{[27
]}

Boffetta, Paolo ^{[28
]}

Vineis, Paolo ^{[1
]}

Riboli, Elio ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England

[2] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA

[3] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany

[4] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[5] Aarhus Univ Hosp, Aalborg Hosp, Dept Med, Aalborg, Denmark

[6] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[7] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[8] Univ Athens, Dept Hyg & Epidemiol, Sch Med, GR-10679 Athens, Greece

[9] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[10] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[11] Natl Canc Inst, Canc Registry, I-20133 Milan, Italy

[12] Natl Canc Inst, Environm Epidemiol Div, I-20133 Milan, Italy

[13] CPO PIemonte & ISI Fdn, Turin, Italy

[14] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[15] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

[16] Publ Hlth Inst Navarra, Pamplona, Spain

[17] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[18] Catalan Inst Oncol ICO IDIBELL, Epidemiol Unit, Barcelona, Spain

[19] Dept Publ Hlth Gipuzkoa, San Sebastian, Spain

[20] Nutr Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[21] Umea Univ, Dept Radiat Sci, Umea, Sweden

[22] Malmo Univ Hosp, Dept Clin Sci, Malmo, Sweden

[23] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[24] Univ Oxford, Epidemiol Unit, Oxford OX1 2JD, England

[25] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge CB2 1TN, England

[26] Elsie Widdowson Lab, MRC Epidemiol Unit, Cambridge, England

[27] Int Agcy Res Canc, Nutr & Hormones Grp, F-69372 Lyon, France

[28] Int Agcy Res Canc, Gene Environm Epidemiol Grp, F-69372 Lyon, France

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2008年 / 93卷 / 11期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

non-Hodgkin's lymphoma; anthropometry; cohort study;

D O I：

10.3324/haematol.13078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50,95% CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.

引用

页码：1666 / 1677

页数：12

共 46 条

[1] Compendium of Physical Activities: an update of activity codes and MET intensities [J].

Ainsworth, BE ;

Haskell, WL ;

Whitt, MC ;

Irwin, ML ;

Swartz, AM ;

Strath, SJ ;

O'Brien, WL ;

Bassett, DR ;

Schmitz, KH ;

Emplaincourt, PO ;

Jacobs, DR ;

Leon, AS .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2000, 32 (09) :S498-S516

[2]

Allison PD., 2010, SURVIVAL ANAL USING

[3] Antidepressant medication use and non-Hodgkin's lymphoma risk: No association [J].

Bahl, S ;

Cotterchio, M ;

Kreiger, N ;

Klar, N .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2004, 160 (06) :566-575

[4] Anthropometric characteristics and risk of multiple myeloma [J].

Blair, CK ;

Cerhan, JR ;

Folsom, AR ;

Ross, JA .

EPIDEMIOLOGY, 2005, 16 (05) :691-694

[5] Re: Body mass index and risk of malignant lymphoma in scandinavian men and women [J].

Bosetti, C ;

Dal Maso, L ;

Negri, E ;

Talamini, RO ;

Montella, M ;

Franceschi, S ;

La Vecchia, C .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (11) :860-861

[6]

Cai ZJ, 1999, WHO TECH REP SER, V887, P1

[7] Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].

Calle, EE ;

Rodriguez, C ;

Walker-Thurmond, K ;

Thun, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1625-1638

[8] Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].

Calle, EE ;

Kaaks, R .

NATURE REVIEWS CANCER, 2004, 4 (08) :579-591

[9] Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: A prospective study [J].

Cerhan, JR ;

Janney, CA ;

Vachon, CM ;

Habermann, TM ;

Kay, NE ;

Potter, JD ;

Sellers, TA ;

Folsom, AR .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 156 (06) :527-535

[10] Anthropometrics, physical activity, related medical conditions, and the risk of non-Hodgkin lymphoma [J].

Cerhan, JR ;

Bernstein, L ;

Severson, RK ;

Davis, S ;

Colt, JS ;

Blair, A ;

Hartge, P .

CANCER CAUSES & CONTROL, 2005, 16 (10) :1203-1214

← 1 2 3 4 5 →