HIV-1 and Ebola virus: The getaway driver nabbed

被引：13

作者：

Luban, J ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 12期

关键词：

D O I：

10.1038/nm1201-1278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a healthy cell, the normal business of Tsg101 protein is as part of the machinery for protein trafficking. It now emerges that two deadly but unrelated viruses, HIV-1 and Ebola, both subvert Tsg101 as an essential step in their life cycles-exiting a cell to restart the cycle of infection.

引用

页码：1278 / 1280

页数：3

共 13 条

[1] Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells [J].

Braaten, D ;

Luban, J .

EMBO JOURNAL, 2001, 20 (06) :1300-1309

[2] Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells [J].

Elbashir, SM ;

Harborth, J ;

Lendeckel, W ;

Yalcin, A ;

Weber, K ;

Tuschl, T .

NATURE, 2001, 411 (6836) :494-498

[3] Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding [J].

Garrus, JE ;

von Schwedler, UK ;

Pornillos, OW ;

Morham, SG ;

Zavitz, KH ;

Wang, HE ;

Wettstein, DA ;

Stray, KM ;

Côté, M ;

Rich, RL ;

Myszka, DG ;

Sundquist, WI .

CELL, 2001, 107 (01) :55-65

[4] EFFECT OF MUTATIONS AFFECTING THE P6 GAG PROTEIN ON HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLE RELEASE [J].

GOTTLINGER, HG ;

DORFMAN, T ;

SODROSKI, JG ;

HASELTINE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3195-3199

[5] P6(GAG) IS REQUIRED FOR PARTICLE-PRODUCTION FROM FULL-LENGTH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MOLECULAR CLONES EXPRESSING PROTEASE [J].

HUANG, MJ ;

ORENSTEIN, JM ;

MARTIN, MA ;

FREED, EO .

JOURNAL OF VIROLOGY, 1995, 69 (11) :6810-6818

[6] Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I [J].

Katzmann, DJ ;

Babst, M ;

Emr, SD .

CELL, 2001, 106 (02) :145-155

[7] Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells [J].

Kikonyogo, A ;

Bouamr, F ;

Vana, ML ;

Xiang, Y ;

Aiyar, A ;

Carter, C ;

Leis, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11199-11204

[8] HIV-I and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress [J].

Martin-Serrano, J ;

Zang, T ;

Bieniasz, PD .

NATURE MEDICINE, 2001, 7 (12) :1313-1319

[9] POSITIONALLY INDEPENDENT AND EXCHANGEABLE LATE BUDDING FUNCTIONS OF THE ROUS-SARCOMA VIRUS AND HUMAN-IMMUNODEFICIENCY-VIRUS GAG PROTEINS [J].

PARENT, LJ ;

BENNETT, RP ;

CRAVEN, RC ;

NELLE, TD ;

KRISHNA, NK ;

BOWZARD, JB ;

WILSON, CB ;

PUFFER, BA ;

MONTELARO, RC ;

WILLS, JW .

JOURNAL OF VIROLOGY, 1995, 69 (09) :5455-5460

[10] Equine infectious anemia virus gag polyprotein late domain specifically recruits cellular AP-2 adapter protein complexes during virion assembly [J].

Puffer, BA ;

Watkins, SC ;

Montelaro, RC .

JOURNAL OF VIROLOGY, 1998, 72 (12) :10218-10221

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