The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review and meta-analysis

被引：126

作者：

Hill, Micah J. ^{[1
]}

Levens, Eric D. ^{[1
,2
]}

Levy, Gary ^{[1
]}

Ryan, Mary E. ^{[3
]}

Csokmay, John M. ^{[1
]}

DeCherney, Alan H. ^{[1
]}

Whitcomb, Brian W. ^{[4
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA

[2] Shady Grove Fertil Reprod Sci Ctr, Rockville, MD USA

[3] Natl Inst Hlth Lib, Bethesda, MD USA

[4] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Div Biostat & Epidemiol, Amherst, MA 01003 USA

来源：

FERTILITY AND STERILITY | 2012年 / 97卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Recombinant luteinizing hormone; recombinant follicle stimulating hormone; in vitro fertilization; assisted reproductive technologies; advanced reproductive age; IN-VITRO FERTILIZATION; FOLLICLE-STIMULATING-HORMONE; HUMAN MENOPAUSAL GONADOTROPINS; CONTROLLED OVARIAN STIMULATION; HIGHLY PURIFIED HMG; LH SUPPLEMENTATION; PREGNANCY RATES; PREMATURE LUTEINIZATION; DOUBLE-BLIND; HUMAN FSH;

D O I：

10.1016/j.fertnstert.2012.01.130

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objective: To evaluate the effect of recombinant LH in assisted reproduction technology (ART) cycles in patients of advanced reproductive age. Design: A systematic review and meta-analysis. Setting: Published randomized controlled clinical trials comparing recombinant LH plus recombinant FSH versus recombinant FSH only in patients of advanced reproductive age. Patient(s): Patients 35 years and older undergoing assisted reproduction. Intervention(s): Recombinant LH plus recombinant FSH controlled ovarian hyperstimulation (COH) versus recombinant FSH stimulation only in assisted reproduction cycles. Main Outcome Measure(s): Implantation and clinical pregnancy. Result(s): Seven trials were identified that met inclusion criteria and comprised 902 assisted reproduction technology cycles. No differences in serum E-2 on the day of hCG administration were reported in any trials. Two trials reported lower oocyte yield and one trial reported lower metaphase II oocyte yield in the recombinant LH-supplemented group. One trial reported higher fertilization rates in the recombinant LH-supplemented group. In a fixed effect model, implantation was higher in the recombinant LH-supplemented group (odds ratio 1.36, 95% confidence interval 1.05-1.78). Similarly, clinical pregnancy was increased in the recombinant LH-supplemented group (odds ratio 1.37, 95% confidence interval 1.03-1.83). Conclusion(s): The addition of recombinant LH to ART cycles may improve implantation and clinical pregnancy in patients of advanced reproductive age. (Fertil Steril (R) 2012;97:1108-14. (C) 2012 by American Society for Reproductive Medicine.)

引用

页码：1108 / +

页数：8

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