The apparent monovalency of human IgG4 is due to bispecificity

被引：23

作者：

Aalberse, RC ^{[1
]}

Schuurman, J ^{[1
]}

van Ree, R ^{[1
]}

机构：

[1] Univ Amsterdam, Expt & Clin Immunol Lab, CLB, NL-1066 CX Amsterdam, Netherlands

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期

关键词：

IgG4; non-precipitating antibody; bispecific antibody; chimeric antibody;

D O I：

10.1159/000024062

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A hypothesis is put forward to explain the apparent monovalency of human lgG4, It is based upon the known instability of the lgG4 hinge. lgG4 is secreted as a regular bivalent antibody, but after secretion interacts with another lgG4 molecule, This interaction results in the exchange of half molecules (a combination of one heavy chain and one light chain) between the two IgG4 molecules. The postulated bispecific lgG4 antibodies can indeed be found in selected human sera following repeated immunization with two non-crossreacting antigens.

引用

页码：187 / 189

页数：3

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