Corneal Neovascularization: An Anti-VEGF Therapy Review

被引：304

作者：

Chang, Jin-Hong ^{[1
]}

Garg, Nitin K. ^{[1
]}

Lunde, Elisa ^{[1
]}

Han, Kyu-Yeon ^{[1
]}

Jain, Sandeep ^{[1
]}

Azar, Dimitri T. ^{[1
]}

机构：

[1] Univ Illinois, Dept Ophthalmol & Visual Sci, Illinois Eye & Ear Infirm, Chicago, IL 60612 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2012年 / 57卷 / 05期

关键词：

anti-VEGF therapy; corneal neovascularization; bevacizumab; ranibizumab; VEGF Trap; silencing RNA; ENDOTHELIAL GROWTH-FACTOR; HERPETIC STROMAL KERATITIS; FACTOR TRAP-EYE; SUBCONJUNCTIVAL BEVACIZUMAB INJECTION; DIABETIC MACULAR EDEMA; ACTIVATING-FACTOR PAF; TOPICAL BEVACIZUMAB; GRAFT-SURVIVAL; CHOROIDAL NEOVASCULARIZATION; OCULAR NEOVASCULARIZATION;

D O I：

10.1016/j.survophthal.2012.01.007

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Corneal neovascularization is a serious condition that can lead to a profound decline in vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity, and may lead to inflammation and edema. Corneal neovascularization occurs when the balance between angiogenic and antiangiogenic factors is tipped toward angiogenic molecules. Vascular endothelial growth factor (VEGF), one of the most important mediators of angiogenesis, is upregulated during neovascularization. In fact, anti-VEGF agents have efficacy in the treatment of neovascular age-related macular degeneration, diabetic retinopathy, macular edema, neovascular glaucoma, and other neovascular diseases. These same agents have great potential for the treatment of corneal neovascularization. We review some of the most promising anti-VEGF therapies, including bevacizumab, VEGF trap, siRNA, and tyrosine kinase inhibitors. (Surv Ophthalmol 57:415-429, 2012. (C) 2012 Elsevier Inc. All rights reserved.)

引用

页码：415 / 429

页数：15

共 142 条

[1] Effect of bevacizumab on corneal neovascularization in experimental rabbit model [J].

Ahmed, Abdulgani ;

Berati, Hasanreisoglu ;

Nalan, Akyurek ;

Aylin, Sepici .

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2009, 37 (07) :730-736

[2]

Amano S, 1998, INVEST OPHTH VIS SCI, V39, P18

[3] Corneal avascularity is due to soluble VEGF receptor-1 [J].

Ambati, Balamurali K. ;

Nozaki, Miho ;

Singh, Nirbhai ;

Takeda, Atsunobu ;

Jani, Pooja D. ;

Suthar, Tushar ;

Albuquerque, Romulo J. C. ;

Richter, Elizabeth ;

Sakurai, Eiji ;

Newcomb, Michael T. ;

Kleinman, Mark E. ;

Caldwell, Ruth B. ;

Lin, Qing ;

Ogura, Yuichiro ;

Orecchia, Angela ;

Samuelson, Don A. ;

Agnew, Dalen W. ;

St. Leger, Judy ;

Green, W. Richard ;

Mahasreshti, Parameshwar J. ;

Curiel, David T. ;

Kwan, Donna ;

Marsh, Helene ;

Ikeda, Sakae ;

Leiper, Lucy J. ;

Collinson, J. Martin ;

Bogdanovich, Sasha ;

Khurana, Tejvir S. ;

Shibuya, Masabumi ;

Baldwin, Megan E. ;

Ferrara, Napoleone ;

Gerber, Hans-Peter ;

De Falco, Sandro ;

Witta, Jassir ;

Baffi, Judit Z. ;

Raisler, Brian J. ;

Ambati, Jayakrishna .

NATURE, 2006, 443 (7114) :993-997

[4] Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration [J].

Avery, RL ;

Pieramici, DJ ;

Rabena, MD ;

Castellarin, AA ;

Nasir, MA ;

Giust, MJ .

OPHTHALMOLOGY, 2006, 113 (03) :363-372

[5]

Avila MP, 2011, RETINA, V32, P10

[6] Effect of Subconjunctival and Intraocular Bevacizumab Injections on Corneal Neovascularization in a Mouse Model [J].

Avisar, Inbal ;

Weinberger, Dov ;

Kremer, Israel .

CURRENT EYE RESEARCH, 2010, 35 (02) :108-115

[7] Subconjunctival bevacizumab for vascularized rejected corneal grafts [J].

Awadein, Ahmed .

JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 2007, 33 (11) :1991-1993

[8] Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation [J].

Bachmann, B. O. ;

Luetjen-Drecoll, E. ;

Bock, F. ;

Wiegand, S. J. ;

Hos, D. ;

Dana, R. ;

Kruse, F. E. ;

Cursiefen, C. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2009, 93 (08) :1075-1080

[9] Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation [J].

Bachmann, Bjoern O. ;

Bock, Felix ;

Wiegand, Stanley J. ;

Maruyama, Kazuichi ;

Dana, M. Reza ;

Kruse, Friedrich E. ;

Luetjen-Drecoll, Elke ;

Cursiefen, Claus .

ARCHIVES OF OPHTHALMOLOGY, 2008, 126 (01) :71-77

[10] Corneal Neovascularization as a Risk Factor for Graft Failure and Rejection after Keratoplasty An Evidence-Based Meta-analysis [J].

Bachmann, Bjorn ;

Taylor, Rod S. ;

Cursiefen, Claus .

OPHTHALMOLOGY, 2010, 117 (07) :1300-U42

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