Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by tubeimoside 1

被引：39

作者：

Yu, LJ ^{[1
]}

Ma, RD ^{[1
]}

Yu, TX ^{[1
]}

机构：

[1] XIAN MED UNIV,DEPT NEUROPHYSIOL,XIAN 710061,PEOPLES R CHINA

来源：

PLANTA MEDICA | 1996年 / 62卷 / 02期

关键词：

tubeimoside; 1; Bolbostemma paniculatum (Maxim); Franquet; Cucurbitaceae; induction of cell differentiation; human promyelocytic leukemia cells;

D O I：

10.1055/s-2006-957831

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two functional parameters evaluated by nitroblue tetrazolium (NET) dye reduction and zymosan particle phagocytosis and a morphological change assessed by the Wright-Giemsa stain of human promyelocytic leukemia cells (HL-60 cells) were used to determine the extent of HL-60 cell differentiation induced by tubeimoside 1. The results revealed that under the action of tubeimoside 1, HL-60 cells could be induced to differentiate to more mature cells with the functional characteristics of granulocytes. Therefore, tubeimoside 1 could be considered as a promising antileukemic agent for further animal trials.

引用

页码：119 / 121

页数：3

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