Absence of mutagenic effects of sodium dichloroacetate

被引:33
作者
Fox, AW
Yang, XQ
Murli, H
Lawlor, TE
Cifone, MA
Reno, FE
机构
[1] CORNING HAZLETON INC, VIENNA, VA 22182 USA
[2] PATHOL TOXICOL CONSULTANTS, FAIRFAX, VA 22031 USA
来源
FUNDAMENTAL AND APPLIED TOXICOLOGY | 1996年 / 32卷 / 01期
关键词
D O I
10.1006/faat.1996.0110
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Sodium dichloroacetate (DCA) is a drug with potential for treating patients with stroke and head injury. Conflicting evidence has been published on the mutagenic potential of DCA. A series of genetic tests for mutagenicity and clastogenicity was carried out on pharmaceutical grade DCA. Four types of mutagenicity test were included, with and without metabolic activation where appropriate. These studies included: (i) Salmonella and Escherichia coli mutation (Ames) tests, (ii) thymidine kinase locus forward mutation in L5178Y mouse lymphoma cells, (iii) tests for chromosomal aberrations in Chinese hamster ovary cells, and (iv) an in vivo rat bone marrow erythroid micronucleus test. In each study, there was no evidence of mutagenic activity attributable to DCA. It is possible that the present test material, of pharmaceutical grade, has fewer impurities than materials studied in previous reports. These data extend, and in some cases contradict, previous published reports on DCA. (C) 1996 Society of Toxicology
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收藏
页码:87 / 95
页数:9
相关论文
共 26 条
[1]   EFFECTS OF DICHLOROACETATE ON BRAIN PYRUVATE-DEHYDROGENASE [J].
ABEMAYOR, E ;
KOVACHICH, GB ;
HAUGAARD, N .
JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) :38-42
[2]   METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].
AMES, BN ;
MCCANN, J ;
YAMASAKI, E .
MUTATION RESEARCH, 1975, 31 (06) :347-363
[3]   EFFECTS OF DICHLOROACETATE IN SPINAL STROKE IN THE RABBIT [J].
BARSAN, WG ;
HEDGES, JR ;
SYVERUD, SA ;
DRONEN, SC ;
DIMLICH, RVW .
LIFE SCIENCES, 1987, 41 (09) :1065-1069
[4]   EFFECT OF DICHLOROACETATE ON RECOVERY OF BRAIN LACTATE, PHOSPHORUS ENERGY METABOLITES, AND GLUTAMATE DURING REPERFUSION AFTER COMPLETE CEREBRAL-ISCHEMIA IN RATS [J].
CHANG, LH ;
SHIMIZU, H ;
ABIKO, H ;
SWANSON, RA ;
FADEN, AI ;
JAMES, TL ;
WEINSTEIN, PR .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (06) :1030-1038
[5]  
CLIVE D, 1987, MUTAT RES, V147, P237
[6]   THE EFFECT OF DICHLOROACETATE ON BRAIN LACTATE LEVELS FOLLOWING INCOMPLETE ISCHEMIA IN THE HYPERGLYCEMIC RAT [J].
COLOHAN, ART ;
WELSH, FA ;
MILLER, ED ;
KASSELL, NF .
STROKE, 1986, 17 (03) :525-528
[7]   PLASMA-CONCENTRATIONS AND METABOLIC EFFECTS OF INTRAVENOUS-SODIUM DICHLOROACETATE [J].
CURRY, SH ;
CHU, PI ;
BAUMGARTNER, TG ;
STACPOOLE, PW .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (01) :89-93
[8]   DICHLOROACETATE ATTENUATES NEURONAL DAMAGE IN A GERBIL MODEL OF BRAIN ISCHEMIA [J].
DIMLICH, RVW ;
MARANGOS, PJ .
JOURNAL OF MOLECULAR NEUROSCIENCE, 1994, 5 (02) :69-81
[9]  
EVANS HJ, 1962, INT REV CYTOL, V13, P221
[10]  
GELERNT M D, 1982, Nutrition and Cancer, V3, P129, DOI 10.1080/01635588109513714