Catalytic enantioselective conjugate addition of indoles to simple α,β-unsaturated ketones

被引：104

作者：

Bandini, M ^{[1
]}

Fagioli, M ^{[1
]}

Melchiorre, P ^{[1
]}

Melloni, A ^{[1
]}

Umani-Ronchi, A ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 31期

关键词：

aluminium; asymmetric catalysis; indole; ketones; Michael reaction;

D O I：

10.1016/S0040-4039(03)01400-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral [AI(salen)Cl] complex (10 mol%) in the presence of 2,6-lutidine (10 mol%) was found to be effective in catalysing the enantioselective Friedel-Crafts-type conjugate addition of indoles (3) to (E)-arylcrotyl ketones (2), furnishing the corresponding P-indolyl ketones in excellent yield and high en antioselectivity (ee up to 89%). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：5843 / 5846

页数：4

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