Effect of Polygala tenuifolia root extract on the tumor necrosis factor-α secretion from mouse astrocytes

被引:37
作者
Kim, HM [1 ]
Lee, EH
Na, HJ
Lee, SB
Shin, TY
Lyu, YS
Kim, NS
Nomura, S
机构
[1] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea
[2] Wonkwang Univ, Sch Med, Iksan 570749, Chonbuk, South Korea
[3] Osaka Univ, Sch Med, Dept Pathol, Osaka 530, Japan
[4] Woosuk Univ, Coll Pharm, Wanju 565701, Chonbuk, South Korea
[5] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea
关键词
Polygala tenuifolia root; tumor necrosis factor-alpha; astrocytes; interleukin-1;
D O I
10.1016/S0378-8741(98)00040-3
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
We investigated whether an aqueous extract of Polygala tenuifolia root (PTAE) inhibits secretion of tumor necrosis factor-alpha (TNF-alpha) from primary cultures of mouse astrocytes, PTAE dose-dependently inhibited the TNF-alpha secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate TNF-alpha secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of TNF-alpha secretion from primary astrocytes by PTAE. Treatment of PTAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion to the level observed with LPS alone. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic co-operative effect of LPS and SP. These results suggest that PTAE may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that PTAE has an anti-inflammatory activity on the central nervous system curing some pathological disease states. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:201 / 208
页数:8
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